 
From Zurich Main Station/Bahnhofquai, take Tram No. 4 towards Tiefenbrunnen as far as the Kreuzstrasse stop (10 min approx.).
Alternatively, from Zurich Main Station, take S-Bahn No. 3 or No. 12 to Stadelhofen station (2 min approx.). Then walk from Stadelhofen station to the Opernhaus (1 min). From the Opernhaus, take Tram No. 4 or No. 2 towards Tiefenbrunnen and travel 1 stop to Kreuzstrasse.
From the Kreuzstrasse tram stop, walk in the same direction as the tram and turn right into Kreuzstrasse. Then take the 1st left into Dufourstrasse. Walk along Dufourstrasse, and take the 2nd right at the Hotel Seegarten Latino into Seegartenstrasse.
Tramway time table

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